Hydrochloride methanol → 1-[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639786ノート

反応式

HRID 1639786 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@@H:12]1[CH2:14][C@H:13]1[CH2:15][NH:16]C(=O)OC(C)(C)C.[ClH:24].CO>CO>[ClH:24].[ClH:24].[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@@H:12]1[CH2:14][C@H:13]1[CH2:15][NH2:16]

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 59334581tert-butyl {[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl)carbamate

生成物 1

HCID 667206571-[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride収率 79%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl {[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}carbamate (343 mg, 1.07 mmol) in methanol (1 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 3 mL) solution, and the mixture was stirred at room temperature for 14 hr. The solvent was concentrated under reduced pressure and the obtained crystals were washed with ethyl acetate to give the title compound (246 mg, yield 79%).

後処理

  1. concentrationThe solvent was concentrated under reduced pressure
  2. washthe obtained crystals were washed with ethyl acetate

出典と根拠

ORDレコード
ord-128c43b9f008436c96c6c9b17e422daa
出典データセット
uspto-grants-2012_02
特許番号
US08110585B2

反応ノート

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