Hydrochloride methanol → 1-[(1S,2S)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochloride
反応式
[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@H:10]3[CH2:12][C@@H:11]3[CH2:13][NH:14]C(=O)OC(C)(C)C)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[ClH:23].CO>CO>[ClH:23].[ClH:23].[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@H:10]3[CH2:12][C@@H:11]3[CH2:13][NH2:14])=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1参加物
4
実験手順
To a solution of tert-butyl {[(1S,2S)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate (1.84 g, 6.11 mmol) in methanol (6 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 18 mL) solution, and the mixture was stirred at room temperature for 15 hr. The solvent was concentrated under reduced pressure to give the title compound (1.69 g, yield 100%).
後処理
- concentrationThe solvent was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b735fdedf4014133bb17eb86c8dfba16
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08110585B2
反応ノート
読み込み中…