Hydrochloride methanol → 1-[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639817ノート

反応式

HRID 1639817 の反応式
[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@@H:10]3[CH2:12][C@H:11]3[CH2:13][NH:14]C(=O)OC(C)(C)C)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[ClH:23].CO>CO>[ClH:23].[ClH:23].[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@@H:10]3[CH2:12][C@H:11]3[CH2:13][NH2:14])=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 59334467tert-butyl {[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate

生成物 1

HCID 667206351-[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl {[(1R,2R)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate (1.71 g, 5.67 mmol) in methanol (6 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 18 mL) solution and the mixture was stirred at room temperature for 15 hr. The solvent was concentrated under reduced pressure to give the title compound (1.61 g, yield 100%).

後処理

  1. concentrationThe solvent was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6199c94954ab46fba2bdc4e35a134e0f
出典データセット
uspto-grants-2012_02
特許番号
US08110585B2

反応ノート

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