Aniline → Aniline, N-(2,2,2-trifluoroethyl)-

HRID 1640234

反応式

HRID 1640234 の反応式
FC(F)(F)S(O[CH2:7][C:8]([F:11])([F:10])[F:9])(=O)=O.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[F:9][C:8]([F:11])([F:10])[CH2:7][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 6115AnilineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

生成物 1

HCID 9596Aniline, N-(2,2,2-trifluoroethyl)-

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

2.5 g (10.7 mmol) 2,2,2-trifluoroethyl trifluoromethanesulphonate were added to 2.0 g (21.5 mmol) aniline in 50 mL xylene and the mixture was refluxed for 2 days. After cooling, the mixture was filtered, washed with DIPE and the filtrate was evaporated down i.vac. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.

後処理

  1. temperaturethe mixture was refluxed for 2 days
  2. temperatureAfter cooling
  3. filtrationthe mixture was filtered
  4. washwashed with DIPE
  5. customthe filtrate was evaporated down i.vac
  6. customThe residue was purified by flash chromatography
  7. customevaporated down i.vac

出典と根拠

ORDレコード
ord-1e0a5ea719cf40c5a311b798f7ce4fb7
出典データセット
uspto-grants-2012_02
特許番号
US08110575B2

関連ノート

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