Benzylamine → Benzyl-(2,2,2-trifluoro-ethyl)-amine

HRID 1640236

反応式

HRID 1640236 の反応式
[F:1][C:2]([F:13])([F:12])[CH2:3]OS(C(F)(F)F)(=O)=O.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[CH2:14]([NH:21][CH2:3][C:2]([F:13])([F:12])[F:1])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

生成物 1

HCID 4962181Benzyl-(2,2,2-trifluoro-ethyl)-amine

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

2.2 g (9.4 mmol) 2,2,2-trifluoroethyltrifluoromethanesulphonate were added to 2.0 g (18.7 mmol) benzylamine in 50 mL xylene and the reaction mixture was refluxed overnight. After cooling the precipitate formed was suction filtered, washed with DIPE and the filtrate was evaporated down using the rotary evaporator. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.

後処理

  1. temperaturethe reaction mixture was refluxed overnight
  2. temperatureAfter cooling the precipitate
  3. customformed
  4. filtrationfiltered
  5. washwashed with DIPE
  6. customthe filtrate was evaporated down
  7. customthe rotary evaporator
  8. customThe residue was purified by flash chromatography
  9. customevaporated down i.vac

出典と根拠

ORDレコード
ord-8a79d718fc0d408cab994cbe2103242d
出典データセット
uspto-grants-2012_02
特許番号
US08110575B2

関連ノート

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