Phenethylamine → 2,2,2-Trifluoro-N-(2-phenylethyl)ethan-1-amine
反応式
[F:1][C:2]([F:13])([F:12])[CH2:3]OS(C(F)(F)F)(=O)=O.[CH2:14]([NH2:22])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C(C)=CC=CC=1>[CH2:14]([NH:22][CH2:3][C:2]([F:13])([F:12])[F:1])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1参加物
4
実験手順
1.9 g (8.3 mmol) 2,2,2-trifluoroethyltrifluoromethanesulphonate were added to 2.0 g (16.5 mmol) phenethylamine in 50 mL xylene and the reaction mixture was refluxed overnight. After cooling the precipitate formed was suction filtered, washed with DIPE and the filtrate washed evaporated down i.vac. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.
後処理
- temperaturethe reaction mixture was refluxed overnight
- temperatureAfter cooling the precipitate
- customformed
- filtrationfiltered
- washwashed with DIPE
- washthe filtrate washed
- customevaporated down i.vac
- customThe residue was purified by flash chromatography
- customevaporated down i.vac
出典と根拠
- ORDレコード
- ord-3b6f770e15b4411da73f674d6141b332
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08110575B2
反応ノート
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