Hydrochloric Acid → 4-Chloro-3-mercapto-2-methylbenzoic acid
反応式
[OH-].[K+].[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[C:6]([CH3:14])[C:5]=1[S:15]C(N(C)C)=O.O.Cl>CO>[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([OH:10])=[O:9])=[C:6]([CH3:14])[C:5]=1[SH:15]参加物
6
実験手順
6.61 g (85% by weight pure, 100.1 mmol) of potassium hydroxide were added to 4.80 g (16.7 mmol) of methyl 4-chloro-3-(dimethylaminocarbonylthio)-2-methylbenzoate in 150 ml of methanol, and the mixture was stirred under reflux for two days. The reaction mixture was freed from the solvent, water was added to the residue, the mixture was acidified with 1M HCl and the solid was removed by filtration. This gave 3.2 g of clean product.
後処理
- temperatureunder reflux for two days
- additionwas added to the residue
- customthe solid was removed by filtration
出典と根拠
- ORDレコード
- ord-5b23f01ce6ff480e90f77064a161718a
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114816B2
反応ノート
読み込み中…