Ethylenediamine → HCID 68601740、化合物

HRID 1640546ノート

反応式

HRID 1640546 の反応式
Cl[C:2]1[CH:3]=[CH:4][N:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[CH:8]=[CH:7]2.[CH2:14]([NH2:17])[CH2:15][NH2:16]>C(Cl)Cl>[CH3:13][O:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[NH:16][CH2:15][CH2:14][NH2:17]

参加物

4

反応物 2

HCID 3301EthylenediamineHCID 222443958-Chloro-2-methoxy-1,5-naphthyridine

生成物 1

HCID 68601740HCID 68601740、化合物収率 51%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
100 °C

実験手順

A mixture of 8-chloro-2-methoxy-[1,5]naphthyridine (commercial; 1.7 g, 8.80 mmol) and ethane-1,2-diamine (1.2 mL, 2 eq.) was heated slowly to 80° C. over 1 h and subsequently up to 100° C. for 2 h. After cooling to rt, the yellow solution was taken up in DCM and successively washed with sat. aq. NaHCO3. The org. layer was concentrated under reduced pressure to afford the title intermediate as a pale yellow oil (981 mg, 51% yield).

後処理

  1. temperatureAfter cooling to rt
  2. washsuccessively washed with sat. aq. NaHCO3
  3. concentrationlayer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-806e442c4a434d4698c807bbab7c71bb
出典データセット
uspto-grants-2012_02
特許番号
US08114867B2

反応ノート

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