Cesium carbonate → 4-(1H-1,2,3-Triazol-1-yl)benzonitrile
反応式
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH:10]1[CH:14]=[CH:13][N:12]=[N:11]1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[N:10]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH:14]=[CH:13][N:12]=[N:11]1参加物
5
反応条件
- 温度
- 80 °C
実験手順
4-Fluorobenzonitrile (0.847 g, 7 mmol), 1H-[1,2,3]triazole (0.483 g, 7 mmol), Cs2CO3 (2.27 g, 7 mmol) and DMF (8 ml) and a magnetic stirrer were placed in a vial. The mixture was heated with stirring for 3 h at 80° C. Extractive work-up (EtOAc/H2O) and subsequent drying (Na2SO4) gave a crude product which was purified on silica giving 0.55 g (46%) of the title intermediate.
後処理
- temperatureThe mixture was heated
- dry with materialExtractive work-up (EtOAc/H2O) and subsequent drying (Na2SO4)
出典と根拠
- ORDレコード
- ord-33856c69903042599a2d88d2be17adc3
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114881B2
反応ノート
読み込み中…