Potassium Hydroxide → 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline

HRID 16407

反応式

HRID 16407 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[CH:10][C:3]=12.[F:11][C:12]1[CH:18]=[C:17]([OH:19])[CH:16]=[CH:15][C:13]=1[NH2:14].[OH-].[K+]>O>[F:11][C:12]1[CH:18]=[C:17]([O:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]3[NH:8][CH:9]=[CH:10][C:3]=23)[CH:16]=[CH:15][C:13]=1[NH2:14]

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 27359194-Amino-3-fluorophenolHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 179793512-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

100 mg (660 μmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine (from example XVIII), 166 mg (1.31 mmol) of 2-fluoro-4-hydroxyaniline and 73.5 mg (1.31 mmol) of powdered potassium hydroxide are heated at 260° C. for 8 hours. For work-up, the mixture is cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated using a rotary evaporator. The residue is purified by preparative HPLC.

後処理

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe organic phase is dried over magnesium sulfate
  3. concentrationconcentrated
  4. customa rotary evaporator
  5. customThe residue is purified by preparative HPLC

出典と根拠

ORDレコード
ord-b6ddfe09432349159627580791e74162
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

関連ノート

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