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4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran → 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-Fluoro-4-nitrophenoxy)-1-benzofuran | HCID 17979342 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 溶媒 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 生成物 | 4-(1-Benzofuran-4-yloxy)-3-fluorophenylamine | HCID 17979304 | — |
反応手順
Under argon, 150 mg (0.55 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1-benzofuran (from example XXII) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), platinum(IV) oxide is added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated using a rotary evaporator.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737153B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-e3cf80b818b84914a527d46ea5c07013 |
| 出典メモ | uspto-grants-2010_06 |