DMF Phosphorus oxychloride → 5-(difluoromethoxy)-1H-indole-3-carboxylic acid
反応式
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[CH:7]2.P(Cl)(Cl)(Cl)=O.CN([CH:22]=[O:23])C.Cl([O-])=[O:25].[Na+].P([O-])(O)(O)=O.[Na+]>O1CCOCC1>[F:13][CH:2]([F:1])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[C:22]([OH:23])=[O:25]参加物
5
実験手順
5-Difluoromethoxyindole (PCT 2007/096395) was formylated in the 3-position using a Vilsmeyer-Haack protocol (phosphorous oxychloride/DMF). The resulting aldehyde was oxidized with sodium chlorite/sodium dihydrogen phosphate in aqueous dioxane. MS (m/e) 227.
出典と根拠
- ORDレコード
- ord-1ab083795a414f71bfc41ecfec8c868f
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114891B2
反応ノート
読み込み中…