1H-Indazole-3-carbonyl chloride → Quinuclidin-4-ylmethyl 1H-indazole-3-carboxylate

反応式

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][C:14]23[CH2:21][CH2:20][N:17]([CH2:18][CH2:19]2)[CH2:16][CH2:15]3)=[O:11])=C1.[NH:22]1C2C(=CC=CC=2)C(C(Cl)=O)=N1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][C:14]23[CH2:21][CH2:20][N:17]([CH2:18][CH2:19]2)[CH2:16][CH2:15]3)=[O:11])=[N:22]1

参加物

反応物 2

HCID 231899901H-Indazole-3-carbonyl chloride

HCID 25234267(Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate

生成物 1

HCID 25234348Quinuclidin-4-ylmethyl 1H-indazole-3-carboxylate

実験手順

Quinuclidin-4-ylmethyl 1H-indazole-3-carboxylate was prepared in a similar manner to (Quinuclidin-4-yl)methyl 1H-indole-3-carboxylate, substituting 1H-indazole-3-carbonyl chloride as the electrophile.

出典と根拠

ORDレコード: ord-9e7e139941414664ad0f005f38a74be4
出典データセット: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08114891B2

反応ノート

読み込み中…