Hydrochloric Acid → (4R)-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride
反応式
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@H:4]([NH:11]C(=O)COC)[CH2:3][CH2:2]1.[ClH:17]>C(O)C>[ClH:17].[NH2:11][C@H:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[O:1][CH2:2][CH2:3]1参加物
4
実験手順
A solution of the above N-[(4R)4-chromanyl]-2-methoxyacetamide (2.2 g, 0.0325 mol) in ethanol (100 ml) and concentrated hydrochloric acid (30 ml) was heated at reflux for 12 hours, then evaporated. A small amount of ethyl acetate was added to the residue and the solid filtered off to give (4R)4-aminochromane hydrochloride (2.3 g), m.p. 261-263° C., chemical purity>95%.
後処理
- temperatureat reflux for 12 hours
- customevaporated
- additionA small amount of ethyl acetate was added to the residue
- filtrationthe solid filtered off
出典と根拠
- ORDレコード
- ord-c6d60625036e4f95912a3301e8890e30
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114991B2
反応ノート
読み込み中…