Hydrochloric Acid → (1R,2S)-1-amino-2-methylindane hydrochloride

HRID 1641379ノート

反応式

HRID 1641379 の反応式
[ClH:1].[CH3:2][C@H:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@@H:4]1[NH:12]C(=O)COC>C(O)C.O>[ClH:1].[NH2:12][C@H:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:11][C@@H:3]1[CH3:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 66739634N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide

生成物 1

HCID 66739261(1R,2S)-1-amino-2-methylindane hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Concentrated hydrochloric acid (8 ml) was added to a solution of N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide (5.9 g, 0.0269 mol) in ethanol and water, and the mixture heated for 12 hours at reflux. The solvent was evaporated and a small amount of ethyl acetate added. The undissolved solid was filtered off to give (1R,2S)-1-amino-2-methylindane hydrochloride (1.0 g) as a solid, chemical purity>95%.

後処理

  1. temperaturethe mixture heated for 12 hours
  2. temperatureat reflux
  3. customThe solvent was evaporated
  4. additiona small amount of ethyl acetate added
  5. filtrationThe undissolved solid was filtered off

出典と根拠

ORDレコード
ord-a361b52d3240489d809eb2c9b5bb01f2
出典データセット
uspto-grants-2012_02
特許番号
US08114991B2

反応ノート

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