Triethylamine → 2,5-dichloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 1641414ノート

反応式

HRID 1641414 の反応式
[CH3:1][O:2][C:3]1[NH:7][N:6]=[C:5]([NH2:8])[CH:4]=1.C(N(CC)CC)C.[Cl:16][C:17]1[N:22]=[C:21](Cl)[C:20]([Cl:24])=[CH:19][N:18]=1>CCO>[Cl:16][C:17]1[N:22]=[C:21]([NH:8][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[NH:7][N:6]=2)[C:20]([Cl:24])=[CH:19][N:18]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2372592,4,5-TrichloropyrimidineHCID 178493288HCID 178493288、化合物

生成物 1

HCID 1784930722,5-dichloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 5-methoxy-1H-pyrazol-3-amine (890 mg, 7.8 mmol) in absolute EtOH (20 ml) were added triethylamine (3.3 ml, 23.6 mmol), 2,4,5-trichloropyrimidine (1.4 g, 7.8 mmol) and the resulting solution was aged at room temperature for 12 hours. The mixture was partitioned between EtOAc and H2O, the organic layer was washed with brine and dried. The solvents were removed under reduced pressure to give the title compound as an oil which crystallized upon standing (1.8 g). m/z: 261.

後処理

  1. customThe mixture was partitioned between EtOAc and H2O
  2. washthe organic layer was washed with brine
  3. customdried
  4. customThe solvents were removed under reduced pressure

出典と根拠

ORDレコード
ord-9acbc967f6cb436e8dd320693ab4faba
出典データセット
uspto-grants-2012_02
特許番号
US08114989B2

反応ノート

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