Hydrochloric Acid → (5-{4-[3-Amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl}-2-thienyl)(4-methylphenyl)ketone

HRID 1641573ノート

反応式

HRID 1641573 の反応式
CC1(C)[O:7][CH2:6][C:5]([NH:30]C(=O)C)([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[S:17][C:18]([C:21](=[O:29])[C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=4)=[CH:19][CH:20]=3)=[CH:12][CH:11]=2)[CH2:4][O:3]1.Cl>C(O)C>[NH2:30][C:5]([CH2:4][OH:3])([CH2:6][OH:7])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[S:17][C:18]([C:21]([C:22]3[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=3)=[O:29])=[CH:19][CH:20]=2)=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57624584N-[2,2-dimethyl-5-(2-{4-[5-(4-methylbenzoyl)-2-thienyl]phenyl}ethyl)-1,3-dioxan-5-yl]acetamide

生成物 1

HCID 57624612(5-{4-[3-Amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl}-2-thienyl)(4-methylphenyl)ketone収率 89.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

N-[2,2-Dimethyl-5-(2-{4-[5-(4-methylbenzoyl)-2-thienyl]phenyl}ethyl)-1,3-dioxan-5-yl]acetamide (0.22 g) was dissolved in ethanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 80° C. for 4 hr. The reaction mixture was concentrated, aqueous potassium carbonate solution was added to the residue, and the precipitated crystals were collected by filtration to give the title compound (163 mg) as brown crystals.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionaqueous potassium carbonate solution was added to the residue
  3. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-a80e1ec1e9114f08b1287a4c7caea993
出典データセット
uspto-grants-2012_02
特許番号
US08114902B2

反応ノート

読み込み中…