Toluene → Diethyl 2-nitrobenzylphosphonate

反応式

[N+:1](C(Br)C1C=CC=CC=1)([O-:3])=[O:2].C([O:14][P:15]([O:19][CH2:20][CH3:21])[O:16][CH2:17][CH3:18])C.[C:22]1([CH3:28])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:20]([O:19][P:15]([CH2:28][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N+:1]([O-:3])=[O:2])(=[O:14])[O:16][CH2:17][CH3:18])[CH3:21]

参加物

反応物 3

HCID 1140Toluene

HCID 31215Triethyl phosphite

HCID 11356361Nitrobenzylbromide

生成物 1

HCID 11277310Diethyl 2-nitrobenzylphosphonate

実験手順

A mixture of 1.02 g of nitrobenzylbromide and 1.08 ml of triethylphosphite in 10 ml of toluene is heated to reflux for 12 hours. From the mixture obtained solvent is evaporated. (2-Nitro-benzyl)-phosphonic acid diethyl ester is obtained.