関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 5H-Pyrrolo[2,3-b]pyrazine | HCID 5370803 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 7-nitro-5H-pyrrolo[2,3-b]pyrazine | HCID 12207192 | — |
反応手順
7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared by adding 5H-pyrrolo[2,3-b]pyrazine (3) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 7-nitro-5H-pyrrolo[2,3-b]pyrazine 5.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08119637B2 |
|---|
| 出典データセット | uspto-grants-2012_02 |
|---|
| ORD ID | ord-154cf4acfdd640b3a18fb50da19058f6 |
|---|
| 出典メモ | uspto-grants-2012_02 |
|---|
