Carbon Dioxide → 2-(Piperidin-2-yl)acetic acid
反応式
S(=O)(=O)(O)O.[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[CH2:12][CH2:13][OH:14].[OH-].[Ba+2].[OH-].C(=O)=[O:19]>O.[O-2].[O-2].[O-2].[Cr+6]>[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[CH2:12][C:13]([OH:19])=[O:14]参加物
7
実験手順
A solution of chromium trioxide (20 g, 200 mmol) in water (300 ml) and concentrated sulfuric acid (40 g, 73.6 ml) was added dropwise in the course of 1.5 h, while cooling with ice, to a solution of 2-piperidineethanol (10.0 g, 10.1 ml, 77.4 mmol) in water (10 ml). The reaction mixture was stirred for 3 h at room temperature. The solution was then rendered alkaline with saturated aqueous barium hydroxide solution. Carbon dioxide was then passed into the solution, and the resulting suspension was filtered through Celite. The filtrate was concentrated in vacuo.
後処理
- filtrationthe resulting suspension was filtered through Celite
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-e0eeb4db7bde439bb25453bd9387c01d
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119633B2
反応ノート
読み込み中…