2-Chloro-5-iodopyridine → HCID 86584373、化合物
反応式
[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]2[CH2:13][NH:14][CH2:15][C@H:9]12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20](I)=[CH:19][N:18]=1>>[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]2[CH2:13][N:14]([C:20]3[CH:19]=[N:18][C:17]([Cl:16])=[CH:22][CH:21]=3)[CH2:15][C@H:9]12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
cis-1-Benzyloctahydropyrrolo[3,4-b]pyrrole (500 mg, 2.48 mmol), prepared as described in (U.S. Pat. No. 5,071,999), and 2-chloro-5-iodopyridine (643 mg, 2.69 mmol), prepared as described in (Tetrahedron Lett. (1993), 34, 7493-7496), were processed as described in Example 1E to provide the title compound as a tan solid (508 mg, 65% yield). MS (DCI/NH3) m/z 314, 316 (M+H)+.
出典と根拠
- ORDレコード
- ord-361522b6ef1247c2ad19306288dce5e8
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119635B2