HCID 57619809、化合物 → HCID 55288821、化合物
反応式
[C:1]([CH2:3][C@H:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]1[NH:10]C(=O)OC(C)(C)C)#[N:2]>CO.Cl.O1CCOCC1>[NH2:10][C@H:5]1[CH2:6][CH2:7][CH2:8][CH2:9][C@@H:4]1[CH2:3][C:1]#[N:2]参加物
5
実験手順
A solution tert-butyl N-[(1S,2R)-2-(cyanomethyl)cyclohexyl]carbamate (2 g) in MeOH (40 mL) and 4 M HCl in dioxane (20 mL) was stirred at room temperature for 2 hours and concentrated in vacuo to provide the title compound as a yellow oil, which was used for the subsequent step without further purification.
後処理
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5d866fdb39624dafadd68d6fe0a7198a
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119661B2
反応ノート
読み込み中…