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Ethyl Acetate → 4-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,4-Difluorobenzonitrile | HCID 77545 | — |
| 反応物 | 4-Amino-2-chlorophenol | HCID 77578 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile | HCID 17979347 | — |
反応手順
2.00 g (14.4 mmol) of 2,4-difluorobenzonitrile, 2.06 g (14.4 mmol) of 3-chloro-4-hydroxyaniline and 3.97 g (28.8 mmol) of potassium carbonate in 20 ml of acetonitrile are heated at RF for one hour. Ethyl acetate is added, the mixture is filtered and the solvent is removed under reduced pressure. The residue is purified by column chromatography (silica gel 60), giving the product which is a regioisomer mixture with a ratio of 62:38.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737153B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-469b7561ac284cd882eeac1cf9b3c0ae |
| 出典メモ | uspto-grants-2010_06 |