4-Hydroxypyrrolidine → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(3-hydroxy-pyrrolidin-1-yl)methanone
反応式
[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=4)[CH2:12][N:11]([C:25](OC4C=CC([N+]([O-])=O)=CC=4)=[O:26])[CH2:10]3)[O:6][N:5]=2)[CH2:3][CH2:2]1.[NH:37]1[CH2:41][CH2:40][CH:39]([OH:42])[CH2:38]1>>[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][CH:16]=4)[CH2:12][N:11]([C:25]([N:37]4[CH2:41][CH2:40][CH:39]([OH:42])[CH2:38]4)=[O:26])[CH2:10]3)[O:6][N:5]=2)[CH2:2][CH2:3]1参加物
3
実験手順
100 mg (0.20 mmol) of the compound from Example 184A and 52 mg (0.6 mmol) of 3-pyrrolidinol were reacted according to the General Method 6. Yield: 50 mg (55% of theory)
出典と根拠
- ORDレコード
- ord-101edf4ee340433db00a4029059f3bd9
- 出典データセット
- uspto-grants-2012_02