N-Hydroxyacetamidine → [3-(3,4-Dimethylphenyl)-5-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl] (morpholin-4-yl)-methanone

反応式

[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](O)=[O:24])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].O[N:27]=[C:28]([NH2:30])[CH3:29]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][CH:11]([C:23]3[O:24][N:30]=[C:28]([CH3:29])[N:27]=3)[CH2:12][N:13]([C:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[O:16])[CH2:14]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

参加物

反応物 2

HCID 30926N-Hydroxyacetamidine

HCID 58002579HCID 58002579、化合物

生成物 1

HCID 58002237[3-(3,4-Dimethylphenyl)-5-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl] (morpholin-4-yl)-methanone

実験手順

100 mg (0.29 mmol) of the compound from Example 130A and 33 mg (0.43 mmol) of N′-hydroxyacetamidine were reacted according to the General Method 2. Yield: 68 mg (61% of theory)

出典と根拠

ORDレコード: ord-0ea2c94d6af54a60a0f26a4dd7b9b9a8
出典データセット: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08119663B2

反応ノート

読み込み中…