1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → 1-({3-[3-(1-Cyclopropylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}carbonyl)piperidine-4-carbonitrile

HRID 1643010ノート

反応式

HRID 1643010 の反応式
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:27](O)=[O:28])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].[CH:30]1([N:33]2[CH2:38][CH2:37][CH:36]([C:39](=[N:41]O)[NH2:40])[CH2:35][CH2:34]2)[CH2:32][CH2:31]1>>[CH:30]1([N:33]2[CH2:38][CH2:37][CH:36]([C:39]3[N:41]=[C:27]([CH:13]4[CH2:14][CH:15]([C:17]5[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=5)[CH2:16][N:11]([C:9]([N:6]5[CH2:7][CH2:8][CH:3]([C:1]#[N:2])[CH2:4][CH2:5]5)=[O:10])[CH2:12]4)[O:28][N:40]=3)[CH2:35][CH2:34]2)[CH2:31][CH2:32]1

参加物

3

反応物 2

HCID 580023321-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acidHCID 723495471-cyclopropyl-N-hydroxypiperidine-4-carboxamidine

生成物 1

HCID 580024541-({3-[3-(1-Cyclopropylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}carbonyl)piperidine-4-carbonitrile

実験手順

155 mg (0.363 mmol) of the compound from Example 100A and 100 mg (0.545 mmol) of the compound from Example 75A were reacted according to the General Method 2. Yield: 76 mg (38% of theory)

出典と根拠

ORDレコード
ord-c2510fbb9a594f95b8642085ff2aae7a
出典データセット
uspto-grants-2012_02
特許番号
US08119663B2

反応ノート

読み込み中…