Hydrochloric Acid → N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-[2-amino-6-(4-pyridinyl)-4-pyrimidinyl]amine

HRID 16433

反応式

HRID 16433 の反応式
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[C:12]3[C:13]([NH2:16])=[N:14][O:15][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[C:4]([F:19])[CH:3]=1.Cl[C:21]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[N:24]=[C:23]([NH2:33])[N:22]=1.Cl>O>[NH2:16][C:13]1[C:12]2[C:7]([O:6][C:5]3[CH:17]=[CH:18][C:2]([NH:1][C:21]4[CH:26]=[C:25]([C:27]5[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=5)[N:24]=[C:23]([NH2:33])[N:22]=4)=[CH:3][C:4]=3[F:19])=[CH:8][CH:9]=[CH:10][C:11]=2[O:15][N:14]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 179792974-(4-Amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amineHCID 223242864-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine

生成物 1

HCID 17979269N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-[2-amino-6-(4-pyridinyl)-4-pyrimidinyl]amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

70 mg (0.27 mmol) of 4-(4-amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine (from example VII) and 55.8 mg (0.27 mmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) are suspended in 4 ml of water, and 0.02 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a lightly colored precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux overnight
  3. customresulting in the formation of a lightly colored precipitate
  4. filtrationThis is filtered off
  5. washwashed repeatedly with water
  6. customdried under high vacuum

出典と根拠

ORDレコード
ord-61b7c47c928949d9baad30b4fe9e65b1
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

関連ノート

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