Acetyl chloride → 8-(Pyridin-4-yl)-2,8-diazaspiro[4.5]decane dihydrochloride

HRID 1643448ノート

反応式

HRID 1643448 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:23][CH2:22][C:10]3([CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.C([Cl:27])(=O)C>C(O)C>[ClH:27].[ClH:27].[N:1]1[CH:2]=[CH:3][C:4]([N:7]2[CH2:23][CH2:22][C:10]3([CH2:14][NH:13][CH2:12][CH2:11]3)[CH2:9][CH2:8]2)=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 59047377tert-Butyl 8-(pyridin-4-yl)-2,8-diazaspiro[4,5]decane-2-carboxylate

生成物 1

HCID 667010648-(Pyridin-4-yl)-2,8-diazaspiro[4.5]decane dihydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
25 °C

実験手順

tert-Butyl 8-(pyridin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (5.671 mmol, 1 eq) was dissolved in analytical grade ethanol (20 ml) and acetyl chloride (28.355 mmol, 3 eq.) was then added at 0° C. The mixture was stirred at 25° C. for 16 h. Thereafter, the solvent was concentrated in vacuo and the residue was dried under a high vacuum to obtain the desired product. Yield: 1.48 g (90%)

後処理

  1. additionwas then added at 0° C
  2. concentrationThereafter, the solvent was concentrated in vacuo
  3. customthe residue was dried under a high vacuum

出典と根拠

ORDレコード
ord-c50502e521be4c7fa624a642f644a572
出典データセット
uspto-grants-2012_02
特許番号
US08119805B2

反応ノート

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