Acetic Acid → N-Butyl-2-thiazolamine
反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH:7](=O)[CH2:8][CH2:9][CH3:10].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(O)(=O)C>ClC(Cl)C>[CH2:7]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)[CH2:8][CH2:9][CH3:10]参加物
6
実験手順
2-aminothiazole (1 g, 10 mmol) and butyraldehyde (1.44 g, 20 mmol) were mixed in dichloroethane (45 ml) and then treated with sodium triacetoxyborohydride (6 g, 28 mmol) and acetic acid (3.6 g 60 mmol). The reaction mixture was stirred at r.t. under a nitrogen atmosphere overnight. The reaction mixture then was quenched by 1N NaOH and extracted with EtOAc. The organic layer was washed with saturated NaHCO3, brine and dried over MgSO4. The solvent was evaporated to give 2-butylaminothiazole as a brown residue (1.02 g).
後処理
- customThe reaction mixture then was quenched by 1N NaOH
- extractionextracted with EtOAc
- washThe organic layer was washed with saturated NaHCO3, brine
- dry with materialdried over MgSO4
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-d2d6e6994991450195bcbb6bf389207b
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119819B2
反応ノート
読み込み中…