Benzaldehyde → 3-Amino-1-benzyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile

反応式

C(OC(=O)[NH:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]#[N:19])[CH:15]=2)[NH:10][CH2:9]1)(C)(C)C.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[NH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:18]#[N:19])[CH:15]=2)[N:10]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:9]1

参加物

反応物 2

HCID 240Benzaldehyde

HCID 66692977tert-Butyl (6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)carbamate

生成物 1

HCID 667576433-Amino-1-benzyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile

実験手順

157A was prepared from 1C and benzaldehyde by procedures analogous to those described in Example 22A, followed by removal of N-Boc protecting group according to the procedures described in Example 22B.

後処理

customfollowed by removal of N-Boc protecting group

出典と根拠

ORDレコード: ord-b87c47be8a964d36a4d4c5163738a1fd
出典データセット: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08119808B2

反応ノート

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