Sulfuryl chloride → Ethyl 6-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate

HRID 1643920ノート

反応式

HRID 1643920 の反応式
[O:1]=[C:2]1[N:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[NH:3]1.S(Cl)([Cl:19])(=O)=O>C(O)(=O)C>[Cl:19][C:13]1[CH:14]=[CH:15][C:4]2[NH:3][C:2](=[O:1])[N:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:5]=2[CH:12]=1

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 303857Ethyl 2-oxo-2,3-dihydro-1H-benzo[D]imidazole-1-carboxylate

生成物 1

HCID 10354291Ethyl 6-chloro-2-oxo-2,3-dihydrobenzimidazole-1-carboxylate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
90 °C

実験手順

A mixture of 7.00 g (33.9 mmol) of ethyl 2-oxo-2,3-dihydrobenzimidazole-1-carboxylate (IV) and 3.02 ml (37.3 mmol) of sulfuryl chloride in acetic acid (90 ml) was stirred at 90° C. for 1 h. The cooled reaction mixture was poured into ice-water. The precipitated solid was filtered off, washed with water, dried in vacuo and recrystallized from ethyl acetate.

後処理

  1. customThe cooled reaction mixture
  2. filtrationThe precipitated solid was filtered off
  3. washwashed with water
  4. customdried in vacuo
  5. customrecrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-ab703d4154b44b05a2319041a0d3e6c1
出典データセット
uspto-grants-2012_02
特許番号
US08119676B2

反応ノート

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