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Methyl Isocyanate → Dihydroqinghaosu Methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | Npc182939 | HCID 456410 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Dihydroqinghaosu Methylcarbamate | HCID 131720552 | 121.4% |
反応手順
A solution of dihydroqinghaosu (284 mg, 1 mmol) in dry CH2Cl2 (6 ml) and methyl isocyanate (63 mg, 1.1 mmol) was refluxed for ca. 2 days. The solution was filtered and evaporated in vacuo at 40° C. to give a solid, which was chromatographed on a silica-gel column with petroleumether/AcOEt 8:2. The fraction obtained was evaporated to give a white powder (217.6 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726203 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-7d998b7fe2794f36a0da66f08e6c5190 |
| 出典メモ | uspto-grants-1998_03 |