Hydrochloric Acid → N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[2-fluoro-4-(1H-pyrrolo[2,3-b]-pyridin-4-yloxy)phenyl]amine

関与物質

役割	名称	HCID	仕込み量
反応物	Hydrochloric Acid	HCID 313	—
反応物	Sodium Bicarbonate	HCID 516892	—
反応物	2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline	HCID 17979351	—
反応物	4-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine	HCID 22324286	—
溶媒	Water	HCID 962	—
生成物	N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[2-fluoro-4-(1H-pyrrolo[2,3-b]-pyridin-4-yloxy)phenyl]amine	HCID 17979301	—

反応条件

温度	100 °C

反応手順

11 mg (50 μmol) of 2-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (from example XX) are suspended in 5 ml of water. 9.3 mg (50 μmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) and 0.01 ml of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. For work-up, the reaction solution is made alkaline with saturated sodium bicarbonate solution and extracted 3× with ethyl acetate, and the extracts are dried over sodium sulfate and concentrated using a rotary evaporator.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07737153B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-1a4f22055d7242a888e06591430201e8
出典メモ	uspto-grants-2010_06