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Ethyl oxoacetate → 7,8-Difluoroquinoxalin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl oxoacetate | HCID 70211 | — |
| 反応物 | 3,4-Difluorobenzene-1,2-diamine | HCID 2736753 | — |
| 反応物 | 6,7-Difluoro-1,2-dihydroquinoxalin-2-one | HCID 6324339 | — |
| 反応物 | 5,6-difluoroquinoxalin-2(1H)-one | HCID 66775376 | — |
| 生成物 | 7,8-Difluoroquinoxalin-2(1H)-one | HCID 66773436 | 64.3% |
反応手順
3,4-Difluorobenzene-1,2-diamine (4.6 g, 31.6 mmol) and ethyl oxoacetate (50 wt % in toluene, 13.0 mL, 63.2 mmol) were reacted as described for Intermediate 152 to give 3.7 g of product as an off white solid, mixture with 30% of the regioisomer 5,6-difluoroquinoxalin-2(1H)-one. The mixture was carried on to the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08124602B2 |
| 出典データセット | uspto-grants-2012_02 |
| ORD ID | ord-214b3da98155467d80fd35df5fc025df |
| 出典メモ | uspto-grants-2012_02 |