化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 3-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-(Methylthio)thiazol-2-amine | HCID 351678 | — |
| 反応物 | 3-(Chlorocarbonyl)phenyl acetate | HCID 12998558 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate | HCID 57571876 | 65% |
反応手順
Following the procedure for the synthesis of example 85, intermediate 511 (0.815 g, 4.10 mmol) dissolved in dry THF (25.0 mL), triethylamine (0.572 mL, 4.10 mmol), and 512 (0.500 g, 3.42 mmol) dissolved in dry THF (10.0 mL) gave 77 (0.681 g, 65%) as a tan solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08124632B2 |
| 出典データセット | uspto-grants-2012_02 |
| ORD ID | ord-87b1021b2334444d9a687967c9394846 |
| 出典メモ | uspto-grants-2012_02 |