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2-Morpholinoethylamine → 3-(4-Nitrophenoxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Morpholinoethylamine | HCID 408285 | — |
| 反応物 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 生成物 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | — |
| 生成物 | N-[2-(4-morpholinyl)ethyl]-3-(4-nitrophenoxy)benzamide | HCID 66745649 | — |
反応手順
Entry 61: 4-(3-Carboxyphenoxy)-1-nitrobenzene was synthesized according to Method A13, Step 2. 4-(3-Carboxyphenoxy)-1-nitrobenzene was coupled with 4-(2-aminoethyl)morpholine according to Method A13, Step 3 to give 4-(3-(N-(2-morpholinylethyl)carbamoyl)phenoxy)-1-nitrobenzene. According to Method A13 Step 4, 4-(3-(N-(2-morpholinylethyl)carbamoyl)phenoxy)-1-nitrobenzene was reduced to 4-(3-(N-(2-morpholinylethyl)carbamoyl)phenoxy)aniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(3-(N-(2-morpholinylethyl)carbamoyl)phenoxy)aniline to afford the urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08124630B2 |
| 出典データセット | uspto-grants-2012_02 |
| ORD ID | ord-0cd832e2dd654970b08c6f7e3e3d6b4b |
| 出典メモ | uspto-grants-2012_02 |