関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl (2E)-2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate | HCID 11782200 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Azoxystrobin | HCID 3034285 | 95.7% |
反応手順
Methyl (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (20 g at 97.1% strength; prepared as described in WO 92/08703) was added to MIBK (77 ml) and water (11 ml), followed by 2-cyanophenyl (8.0 g), DABCO (0.07 g) and potassium carbonate (14.1 g). The reaction was heated to 80° C. and monitored for the end of the reaction (complete after 8 hours). The reaction mixture was washed with water at 80° C. Analysis of the MIBK layer revealed a 95.7% yield of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08124761B2 |
|---|
| 出典データセット | uspto-grants-2012_02 |
|---|
| ORD ID | ord-b0d822d89ec344f3bae619bea0e67e5e |
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| 出典メモ | uspto-grants-2012_02 |
|---|
