関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 反応物 | Dabco | HCID 9237 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl (2E)-2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate | HCID 11782200 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Azoxystrobin | HCID 3034285 | 97.2% |
反応手順
Methyl (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (98.4 g at 97.7% strength; prepared as described in WO 92/08703) was added to MIBK (214 g), and heated to 45-50° C. 2-cyanophenyl (40.1 g), potassium carbonate (63.4 g) and DABCO (0.51 g) were added and the temperature was raised to 80° C. and held at this temperature for 4.5 hours. Water (316 g) was added and agitation continued for 30 minutes before settling and separating the aqueous layer. Analysis of the MIBK solution revealed a 97.2% yield of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08124761B2 |
|---|
| 出典データセット | uspto-grants-2012_02 |
|---|
| ORD ID | ord-c00619b0959b4581be75fdba65f25472 |
|---|
| 出典メモ | uspto-grants-2012_02 |
|---|
