2,2-Dimethylsuccinic anhydride → 4-(4-{4-[(1-Ethyl-4-methyl-4H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid

HRID 1645347

反応式

HRID 1645347 の反応式
ClC1C2C=C(C(NC3C=CC(N4CCN(C(=O)CC(C)(C)C(O)=O)CC4)=NC=3)=O)SC=2C=CC=1.[CH2:35]([N:37]1[C:45]2[C:40](=[C:41]([CH3:46])[CH:42]=[CH:43][CH:44]=2)[CH:39]=[C:38]1[C:47]([NH:49][C:50]1[CH:55]=[CH:54][C:53]([CH:56]2[CH2:61][CH2:60][N:59]([C:62](=[O:70])[CH2:63][C:64]([CH3:69])([CH3:68])[C:65]([OH:67])=[O:66])[CH2:58][CH2:57]2)=[CH:52][CH:51]=1)=[O:48])[CH3:36].N1CCC(C2C=CC(NC(C3N(CC)C4C(C=3)=C(C)C=CC=4)=O)=CC=2)CC1.CC1(C)CC(=O)OC1=O>>[CH2:35]([N:37]1[C:45]2[C:40]([CH:41]([CH3:46])[CH:42]=[CH:43][CH:44]=2)=[CH:39][CH:38]1[C:47]([NH:49][C:50]1[CH:51]=[CH:52][C:53]([CH:56]2[CH2:57][CH2:58][N:59]([C:62](=[O:70])[CH2:63][C:64]([CH3:68])([CH3:69])[C:65]([OH:67])=[O:66])[CH2:60][CH2:61]2)=[CH:54][CH:55]=1)=[O:48])[CH3:36]

参加物

5

反応物 4

HCID 870672,2-Dimethylsuccinic anhydrideHCID 462078284-(4-{5-[(4-Chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acidHCID 593651344-(4-{4-[(1-ethyl-4-methyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acidHCID 667723921-ethyl-4-methyl-1H-indole-2-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

生成物 1

HCID 667723774-(4-{4-[(1-Ethyl-4-methyl-4H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid

実験手順

With a method similar to that used for the preparation of 4-(4-{5-[(4-chloro-benzo[b]thiophene-2-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-2,2-dimethyl-4-oxo-butyric acid, 4-(4-{4-[(1-ethyl-4-methyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acid was prepared from 1-ethyl-4-methyl-1H-indole-2-carboxylic acid (4-piperidin-4-yl-phenyl)-amide and 2,2-dimethylsuccinic anhydride. LCMS for C29H35N3O4 calcd. (m/e) 489, observed 490 (M+H).

出典と根拠

ORDレコード
ord-b85c8fdf67f94dcab7d1dd502c3a8771
出典データセット
uspto-grants-2012_02
特許番号
US08124766B2

関連ノート

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