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Solketal → HCID 178431368、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Solketal | HCID 7528 | — |
| 反応物 | 4-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium | HCID 9877446 | — |
| 反応物 | 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775847 | — |
| 反応物 | HCID 178505474 | HCID 178505474 | — |
| 生成物 | HCID 178431368 | HCID 178431368 | 14.1% |
反応手順
The same procedure as in the step (10b) of Example 10 and the step (14b) of Example 14, the step (5f) of Example 5, the steps (11h) and (11i) of Example 11 was repeated using solketal, 4-chloro-2,3-dimethylpyridine 1-oxide, and 5-fluoro-1H-benzimidazole-2-thiol to obtain the title compound (210 mg, yield: 14.1%) as a white solid. Note that methanol was used as a solvent instead of ethanol in the same operation as in the step (5f).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08124780B2 |
| 出典データセット | uspto-grants-2012_02 |
| ORD ID | ord-ff6610614c054fd3bb2a3f0cc5d2356c |
| 出典メモ | uspto-grants-2012_02 |