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4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile → 4-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile | HCID 240806 | — |
| 反応物 | 4-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroaniline | HCID 16037965 | — |
| 生成物 | 4-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]benzonitrile | HCID 17979293 | — |
反応手順
Analogously to example 25, the title compound is synthesized from 51 mg (0.21 mmol) of [3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine (from example XIX) and 54 mg (0.22 mmol) of 4-[(2-amino-6-chloropyrimidin-4-yl)amino]benzonitrile (from example XLVII). Purification by preparative HPLC gives the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737153B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-a970582485954ea6b2c103c6a237904d |
| 出典メモ | uspto-grants-2010_06 |