化工社化工社 化学情報印刷レポート · 研究参考用
N-Carbethoxyphthalimide → N-(1-benzylpyrrolidin-3-yl)phthalimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Carbethoxyphthalimide | HCID 31187 | — |
| 反応物 | 1-Benzyl-3-aminopyrrolidine | HCID 2756613 | — |
| 溶媒 | Methyl Chloride | HCID 6327 | — |
| 生成物 | N-(1-benzylpyrrolidin-3-yl)phthalimide | HCID 6711061 | 73.3% |
反応手順
10.0 g of 3-amino-1-benzylpyrrolidine was dissolved into 10 ml of chloromethane, to which 12.4 g of N-ethoxycarbonylphthalimide was added and stirred at a room temperature for 10 hours. The solvent was distilled off, diethyl ether was added and insoluble matters were filtered out. The filtrate was concentrated and purified on silica gel column chromatography, to obtain 12.70 g of the above-captioned compound (yield: 73%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05177089 |
| 出典データセット | uspto-grants-1993_01 |
| ORD ID | ord-83ee5e04305e48a0b95569b7c9462139 |
| 出典メモ | uspto-grants-1993_01 |