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N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide → 3-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide | HCID 15045352 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 生成物 | 3-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine | HCID 15045353 | 100.3% |
反応手順
1.03 g of N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide was dissolved in 50 ml of ethanol, to which 2 ml of hydrazine monohydrate was added and refluxed under heating for 14 hours. The solvent was distilled off and an aqueous diluted solution of sodium hydroxide was added to the residue and extracted with chloroform. After drying with anhydrous magnesium sulfate, the solvent was distilled off, to obtain 0.68 g of the above-captioned compound (yield: 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05177089 |
| 出典データセット | uspto-grants-1993_01 |
| ORD ID | ord-7133ce3a17224f1e9223063767953259 |
| 出典メモ | uspto-grants-1993_01 |