N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide → 3-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine

HRID 1645849

反応式

HRID 1645849 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH:15]([N:18]3C(=O)C4=CC=CC=C4C3=O)[CH2:14]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)C.O.NN>[NH2:18][CH:15]1[CH2:16][CH2:17][N:13]([CH2:12][CH2:11][C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:14]1

参加物

4

反応物 1

HCID 15045352N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide

生成物 1

HCID 150453533-Amino-1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidine収率 100.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 24654Hydrazine hydrate (1:1)溶媒

実験手順

1.03 g of N-(1-(2-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)phthalimide was dissolved in 50 ml of ethanol, to which 2 ml of hydrazine monohydrate was added and refluxed under heating for 14 hours. The solvent was distilled off and an aqueous diluted solution of sodium hydroxide was added to the residue and extracted with chloroform. After drying with anhydrous magnesium sulfate, the solvent was distilled off, to obtain 0.68 g of the above-captioned compound (yield: 100%).

後処理

  1. additionwas added
  2. temperaturerefluxed
  3. temperatureunder heating for 14 hours
  4. distillationThe solvent was distilled off
  5. additionan aqueous diluted solution of sodium hydroxide was added to the residue
  6. extractionextracted with chloroform
  7. dry with materialAfter drying with anhydrous magnesium sulfate
  8. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-7133ce3a17224f1e9223063767953259
出典データセット
uspto-grants-1993_01
特許番号
US05177089

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