Piperidine → 3,4-Dihydro-5-[3-(1-piperidinyl)propoxy]-1(2H)-isoquinolinone

HRID 1645916ノート

反応式

HRID 1645916 の反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH2:8][CH2:9][NH:10][C:11]2=[O:16].[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>C(O)C>[N:17]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:7]=2[CH2:8][CH2:9][NH:10][C:11]3=[O:16])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

参加物

4

反応物 2

HCID 8082PiperidineHCID 110755405-(3-Chloropropoxy)-3,4-dihydroisoquinolin-1(2H)-one

生成物 1

HCID 183695103,4-Dihydro-5-[3-(1-piperidinyl)propoxy]-1(2H)-isoquinolinone収率 61%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 0.6 g (2.5 mmol) of 5-(3-chloropropoxy)-3,4-dihydro-1(2H)-isoquinolinone and 0.6 ml (10 mmol) of piperidine in 30 ml of ethanol was refluxed for 40 hours. The mixture was concentrated, dissolved in chloroform and washed with saturated sodium bicarbonate. The organic layer was dried and concentrated. The solid was recrystallized from water to provide 0.44 g (61%) of the desired product; mp 112°-114°.

後処理

  1. temperaturewas refluxed for 40 hours
  2. concentrationThe mixture was concentrated
  3. dissolutiondissolved in chloroform
  4. washwashed with saturated sodium bicarbonate
  5. customThe organic layer was dried
  6. concentrationconcentrated
  7. customThe solid was recrystallized from water

出典と根拠

ORDレコード
ord-f83c02719f95441f9576a7189413742b
出典データセット
uspto-grants-1993_01
特許番号
US05177075

反応ノート

読み込み中…