Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 1645982ノート

反応式

HRID 1645982 の反応式
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 19100972Ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

生成物 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate, extracted ten times using 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. extractionextracted ten times
  2. dry with materialdried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-ac181c093a2649b2b367672a968e5b01
出典データセット
uspto-grants-1993_01
特許番号
US05177210

反応ノート

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