(S)-methyl 2-(benzylamino)propanoate → N-benzyl-L-alanine
反応式
C[O:2][C:3](=[O:14])[C@H:4]([CH3:13])[NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O>[CH2:6]([NH:5][C@H:4]([C:3]([OH:14])=[O:2])[CH3:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1参加物
3
実験手順
333 g (1.72 mmol) of N-benzylalanine methyl ester (J. Chem. Soc. 4374 (1952)) are heated under reflux overnight with 860 ml of water. Product which has deposited is filtered off with suction and the filtrate is extracted once with tert.-butyl methyl ether. The aqueous solution is concentrated and the crystals obtained are dried over phosphorus pentoxide in a desiccator with the first crystal fraction.
後処理
- filtrationProduct which has deposited is filtered off with suction
- extractionthe filtrate is extracted once with tert.-butyl methyl ether
- concentrationThe aqueous solution is concentrated
- customthe crystals obtained
- dry with materialare dried over phosphorus pentoxide in a desiccator with the first crystal fraction
出典と根拠
- ORDレコード
- ord-1b0e1e81dd0e4499bcd3ed4413c27ee9
- 出典データセット
- uspto-grants-1993_01
- 特許番号
- US05177210
反応ノート
読み込み中…