Water → Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

HRID 1646003ノート

反応式

HRID 1646003 の反応式
[CH2:1]([N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8])[CH:2]=[CH2:3].O.[NH:14]1[CH2:17][CH2:16][CH:15]1C(O)=O>C1(C)C=CC=CC=1>[N:14]12[CH2:17][CH2:16][CH:15]1[CH2:3][CH:2]1[CH:11]2[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:1]1

参加物

5

反応物 3

HCID 962WaterHCID 17288Azetidinecarboxylic AcidHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

生成物 1

HCID 54190177Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

17.1 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate are heated under reflux overnight in a water separator with 10 g (0.1 mol) of azetidine-2-carboxylic acid in 200 ml of toluene. Unreacted amino acid is filtered off with suction, the filtrate is concentrated and the residue is distilled.

後処理

  1. filtrationUnreacted amino acid is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-65e950eb01954877b28171df6385e628
出典データセット
uspto-grants-1993_01
特許番号
US05177210

反応ノート

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