Potassium Carbonate → 2,9-Diazatricyclo[5.3.0.0,2,5]decane

HRID 1646004ノート

反応式

HRID 1646004 の反応式
[N:1]12[CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>O>[N:1]12[CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][NH:4][CH2:5]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 54190177Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

生成物 1

HCID 162289032,9-Diazatricyclo[5.3.0.0,2,5]decane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

13.7 g (65.1 mmol) of ethyl 1,4-diazatricyclo[6.2.0.02,6 ]decane-4-carboxylate are heated under reflux overnight with 42 g of Ba(OH)2.8H2O in 150 ml of water. Potassium carbonate is added, barium carbonate is filtered off with suction and the filtrate is extracted ten times using 100 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. filtrationbarium carbonate is filtered off with suction
  2. extractionthe filtrate is extracted ten times
  3. dry with materialThe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-3f63fa43df484b03a459c9099c6523cc
出典データセット
uspto-grants-1993_01
特許番号
US05177210

反応ノート

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