Potassium Carbonate → Decahydropyrrolo[3,4-b]pyrrolizine

HRID 1646006ノート

反応式

HRID 1646006 の反応式
[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>Cl>[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][NH:4][CH2:5]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 53870311Ethyl 1,4-diazatricyclo[6.3.0.02,6]undecane-4-carboxylate

生成物 1

HCID 16227934Decahydropyrrolo[3,4-b]pyrrolizine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

9 g (40 mmol) of ethyl 1,4-diazatricyclo[6.3.0.02,6 ]undecane-4-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-702abfdf4e02406098aa7935e3ca8612
出典データセット
uspto-grants-1993_01
特許番号
US05177210

反応ノート

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